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Updated: Apr 21, 2026

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
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对DNMT3A的自身抑制和组织素H3诱导激活的结构洞察力

Xue Guo1, Ling Wang1, Jie Li2

  • 11] Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China [2] State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, China.

Nature
|November 11, 2014
PubMed
概括

基因甲基转移酶3A (DNMT3A) 通过自身结构被抑制,但被基因素H3尾部激活. 这种基因组相互作用释放自身抑制,使DNA在特定基因组位点的甲基化.

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