蚊子对人类偏好的进化与一种气味受体有关
Carolyn S McBride1, Felix Baier2, Aman B Omondi3
11] Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, New York 10065, USA [2] Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10065, USA.
Nature
|November 14, 2014
概括
雌性蚊子,如埃及蚊虫 (Aedes aegypti),进化为更喜欢人类的气味,增加疾病传播. 这种转变与家用蚊子种群中的特定气味受体AaegOr4有关.
科学领域:
- 媒介性疾病生态学 媒介性疾病生态学
- 进化遗传学的进化遗传学
- 化学生态化学生态学
背景情况:
- 雌性蚊子是人类疾病的重要载体,如登革热,黄热病和 chikungunya.
- 埃塞斯埃吉普蒂的"家用"形式首选咬人,与其祖先的"森林"形式不同,其目标是动物.
研究的目的:
- 为了调查Aedes aegypti的国内和森林形式之间寻找宿主行为的进化分歧.
- 确定家用蚊子对人类气味的偏好背后的遗传和分子机制.
主要方法:
- 从肯尼亚收集和实验室殖民的家用和森林Aedes aegypti形式.
- 嗅觉行为测试,以评估对人类和动物气味的偏好.
- 基因表达分析和气味受体的功能特征.
主要成果:
- 在这两种埃及甲虫 (Aedes aegypti) 形式之间,在气味偏好方面观察到明显的差异.
- 在家用形式中发现了气味受体AaegOr4的表达和连接体敏感度的增加.
- AaegOr4被确定为人类气味中关键化合物的受体.
结论:
- 人类嗅觉偏好的演变与AegOr4嗅觉受体的变化密切相关.
- 这项研究为疾病载体适应人类宿主提供了罕见的遗传洞察力.
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