由于胸前大动脉疾病和与心血管风险因素相关的死亡率
David Sidloff1, Edward Choke2, Philip Stather2
1From the Department of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Cardiovascular Biomedical Research Unit, Leicester, UK (D.S., E.C., P.S., M.B., R.S.); and Department of Health Sciences, University of Leicester, Leicester, UK (J.T.). ds343@le.ac.uk.
Circulation
|November 15, 2014
概括
胸前大动脉动脉瘤 (TAA) 和大动脉解剖 (AD) 的死亡率在全球范围内正在下降,这与血压和BMI等心血管风险因素有关. 公共卫生工作可以进一步减少这些大动脉疾病死亡.
科学领域:
- 心血管流行病学心血管流行病学
- 公共卫生研究 公共卫生研究
- 大动脉疾病监测监测
背景情况:
- 胸前大动脉疾病死亡率的时间趋势在很大程度上仍然没有特征.
- 这项研究调查了胸前大动脉动脉瘤 (TAA) 和大动脉剖析 (AD) 的死亡率趋势.
- 这项研究旨在将这些趋势与已确定的心血管风险因素联系起来.
研究的目的:
- 分析TAA和AD的全球死亡率趋势.
- 检查心血管风险因素趋势与大动脉疾病死亡率之间的关联.
- 为减少大动脉疾病死亡率的公共卫生战略提供信息.
主要方法:
- 利用了来自世卫组织死亡数据库 (1994-2010年) 的疾病国际分类代码.
- 从世卫组织来源提取了心血管风险因素数据 (1946-2010年).
- 进行了生态回归分析,将18个世卫组织成员国的风险因素趋势与死亡率趋势相关联.
主要成果:
- 一般来说,TAA和AD的死亡率呈现下降趋势,但在特定国家 (匈牙利,罗马尼亚,日本,丹麦) 有显著的例外.
- 来自TAA的死亡率与静脉血压,胆固醇和体重指数趋势有线性关系.
- 缩血压和体重指数的趋势显示出与男性和女性AD死亡率的具体关联;吸烟趋势没有关联.
结论:
- 人口层面的数据表明,TAA和AD死亡率有所下降.
- 观察到的国际死亡率趋势的变化可能归因于心血管风险因素在人口层面的变化.
- 针对心血管风险因素的公共卫生干预措施有可能进一步降低TAA和AD死亡率.
相关概念视频
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
564
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
564
01:15Thoracic Aorta
2.5K
The thoracic section of the aorta begins at the T5 vertebra and extends to the T12 level at the diaphragm, initially progressing through the mediastinum to the left of the spinal column. Throughout its course in the thoracic segment, the thoracic aorta emits various offshoots known collectively as visceral and parietal branches. The branches that predominantly supply blood to visceral organs are termed visceral branches and include bronchial, pericardial, esophageal, and mediastinal arteries,...
2.5K
01:30Aneurysm I: Introduction
642
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
642
01:30Coronary Artery Disease I: Introduction
1.7K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.7K
01:27Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
863
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
863
01:15Aortic Regurgitation I: Introduction
1.5K
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
1.5K