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Updated: Apr 21, 2026

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
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瘤基因监管. 瘤基因监管. 一种通过非编码的基因间元素的体质突变形成的瘤性超级增强剂

Marc R Mansour1, Brian J Abraham2, Lars Anders2

  • 1Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6BT, UK.

Science (New York, N.Y.)
|November 15, 2014
PubMed
概括

某些人类癌症利用超级增强剂来驱动瘤基因表达. 这项研究揭示了突变如何通过招募MYB转录因子在T细胞急性淋巴细胞白血病 (T-ALL) 中产生新的超级增强剂.

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