埃多克萨班对穿孔活检后出血的影响,并通过4因子前列红素复合物缩物逆转出血
Hamim Zahir1, Karen S Brown2, Alexander G Vandell2
1From Daiichi Sankyo Pharma Development, Edison, NJ (H.Z., K.S.B., A.G.V., M.D., V.D., W.F., L.H., M.A.G., H.J.L.); Daiichi Sankyo Inc., Parsippany, NJ (J.-F.M.); Quintiles Inc., Overland, KS (B.L.); CSL Behring GmbH, Marburg, Germany (A.F.); and Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.M.A.). hzahir@dsi.com.
四因子前激素复合缩物 (4F-PCC) 有效地逆转了抗凝剂edoxaban引起的出血. 在健康人群中,50 IU/kg的4F-PCC剂量完全逆转了出血持续时间和血栓潜力.
科学领域:
- 药理学 药理学是指药理学的学科.
- 血液静止和血栓形成
- 临床试验 临床试验
背景情况:
- 埃多克萨班是一种口服的XA因子抑制剂,用于预防心房动和静脉血栓栓塞的中风.
- 这项研究评估了使用4因子前列红复合物缩物 (4F-PCC) 逆转edoxaban的抗凝剂作用.
研究的目的:
- 评估4F-PCC在逆转埃多克萨班诱导出血的疗效及其对静血生物标志物的影响.
- 为了确定4F-PCC对出血测量的剂量依赖逆转效应.
主要方法:
- 一个双盲的,随机的,安慰剂控制的,双向交叉的第一阶段研究.
- 健康的受试者接受了埃多克萨班 (60毫克),随后是静脉注射4F-PCC (10,25或50 IU/kg) 的不同剂量.
- 评估出血的持续时间,出血量,前血时间和内源性血潜力.
主要成果:
- 4F-PCC表明,埃多克萨班的效果因剂量而有所逆转.
- 在50 IU/kg 4F-PCC时,观察到完全逆转出血持续时间和内源性血栓激素潜力.
- 在50 IU/kg时,观察到前列血时间的部分逆转和出血量的类似趋势.
结论:
- 一剂50 IU/kg的4F-PCC有效地逆转了edoxaban的抗凝剂作用,包括出血持续时间和血栓潜力.
- 4F-PCC在健康受试者中与埃多克萨班联合使用时是安全的,并且耐受性良好.
- 50 IU/kg 4F-PCC是逆转edoxaban抗凝剂的一个潜在选择.
相关概念视频
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Venous Thrombosis III: Interprofessional Care
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Extrinsic and Intrinsic Pathways of Hemostasis
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
Clot Retraction and Fibrinolysis
Disorders of Hemostasis
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.


