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Updated: Apr 20, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

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由IAPP驱动的代谢重编程在体内诱导p53缺乏瘤的回归

Avinashnarayan Venkatanarayan1, Payal Raulji2, William Norton3

  • 11] Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA [2] Department of Translational Molecular Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA [3] Graduate School of Biomedical Sciences, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA [4] Metastasis Research Center, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.

Nature
|November 20, 2014
PubMed
概括

准p53家族成员p63和p73为治疗p53缺乏癌症提供了一个新的策略. 删除特定的p63/p73形式会通过上调胺,抑制瘤生长的酸来触发瘤回归.

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