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Updated: Apr 14, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
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发现了氧化核酸的聚合酶诱导的细胞毒性

Bret D Freudenthal1, William A Beard1, Lalith Perera1

  • 1Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, North Carolina 27709-2233, USA.

Nature
|November 20, 2014
PubMed
概括

氧化应激会损害DNA的构建块,导致突变和疾病. 这项研究揭示了人类DNA聚合酶β如何插入氧化瓜核酸,导致DNA损伤和潜在的细胞死亡.

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