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鼠标调节性DNA景观揭示了 cis-调节性进化的全球原则

Jeff Vierstra1, Eric Rynes1, Richard Sandstrom1

  • 1Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.

Science (New York, N.Y.)
|November 21, 2014
PubMed
概括

哺乳动物基因组显示了调节性DNA的广泛重新连接,保存的转录因子结合点在细胞类型中重新配置. 这种演变涉及监管要素的创新,损失和营业额,但仍然保持了整体的TF约束站点分数.

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