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神经元通过在视网膜中定位VEGF来限制血管生成

Keisuke Okabe¹, Sakiko Kobayashi², Toru Yamada³

¹The Laboratory of Vascular Biology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; Department of Plastic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

|November 24, 2014

概括

视网膜神经元通过控制血管内皮生长因子 (VEGF) 来调节血管生长. 在神经元中删除VEGFR2会导致异常的血管生长,影响眼睛的发育和疾病.

科学领域:

神经科学是一个神经科学.
发展生物学发展生物学
眼科医生眼科眼科

背景情况:

哺乳动物的血管和神经系统表现出显著的解剖和功能相互作用.
神经指导对于在发育过程中建立这些系统之间的平行关系至关重要.

研究的目的:

为了研究眼睛发育和疾病中的新型神经血管相互作用.
阐明VEGFR2在视网膜神经元中的有关血管生成的作用.

主要方法:

在视网膜神经元中VEGFR2的遗传删除.
对视网膜中的血管生成和血管密度的分析.
调查VEGF蛋白水平和神经元的吞.

主要成果:

VEGFR2在视网膜神经元中高度表达,而不仅仅是内皮细胞.
神经元VEGFR2缺乏导致错误的血管生成和血管密度增加.
这种误导是由于VEGF被VEGFR2缺陷神经元所吞的VEGF不足造成的.
缺少神经元VEGFR2促进异常再生血管生成在缺血性视网膜病变.

结论:

视网膜神经元在定位VEGF以控制血管化方面发挥着前所未有的作用.
这项研究揭示了一种非正规的神经血管交叉机制,调节眼睛中的血管生成.
这种机制的失调有助于在诸如缺血性视网膜病变等疾病中导致病态血管生成.

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