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基于纸张的合成基因网络.

Keith Pardee1, Alexander A Green1, Tom Ferrante2

  • 1Wyss Institute for Biological Inspired Engineering, Harvard University, Boston, MA 02115, USA; Department of Biomedical Engineering and Center of Synthetic Biology, Boston University, Boston, MA 02215, USA.

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这项研究引入了一种基于纸张的无细胞合成生物学平台,使得基因电路在实验室外部署成为可能. 这项创新为全球卫生和研究提供了可访问,可在现场部署的诊断和生物传感器.

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科学领域:

  • 合成生物学 合成生物学
  • 生物技术是生物技术.
  • 分子诊断学 分子诊断学

背景情况:

  • 合成基因网络为生物工程提供了强大的工具,但通常仅限于实验室环境.
  • 现有的方法缺乏用于在体内或体外实验室环境之外部署工程基因电路的多功能平台.

研究的目的:

  • 为合成生物学应用开发一个体外纸质平台.
  • 为了使工程基因电路在各种环境中安全和经济有效地部署.
  • 为基于现场的合成生物学技术创造一个多功能媒介.

主要方法:

  • 使用商业上可用的无细胞系统,冷干燥到纸上.
  • 为视觉检测设计具有色度输出的基因电路.
  • 为现场使用制造低成本的电子光学接口.
  • 通过小分子和RNA,快速原型和体外诊断来证明执行.

主要成果:

  • 成功开发了一个稳定的,基于纸张的平台,用于无细胞合成生物学.
  • 对于小分子和RNA启动的遗传开关的证明实用性.
  • 工程可编程的体外诊断,包括葡萄糖和埃博拉病毒传感器.
  • 实现了合成生物学技术的廉价,无菌和非生物分布.

结论:

  • 这种基于纸张的平台为实验室之外的合成生物学提供了一个多功能且易于访问的场所.
  • 这项技术促进了工程基因电路的安全部署,用于临床,全球卫生,工业,研究和教育领域的应用.
  • 该平台支持开发可在现场部署的诊断和生物传感器.