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Updated: Apr 20, 2026

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杜基因酶DUBA是T细胞中介质素-17产生的一种后翻译制动剂

Sascha Rutz1, Nobuhiko Kayagaki2, Qui T Phung3

  • 1Department of Immunology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA.

Nature
|December 4, 2014
PubMed
概括

双双化酶DUBA抑制了T-辅助17 (TH17) 细胞对IL-17A (IL-17A) 的产生. 缺乏DUBA的T细胞显示自身免疫性炎症恶化,确定DUBA是关键的调节剂.

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