组织寄居的巨增强剂景观是由当地的微环境塑造的
Yonit Lavin1, Deborah Winter2, Ronnie Blecher-Gonen2
1Department of Oncological Sciences, Immunology Institute and the Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Cell
|December 7, 2014
概括
组织寄居的巨细胞维持器官的稳态. 它们的染色质景观,对身份至关重要,是由发育起源和微环境塑造的,揭示了巨细胞群中的可塑性.
科学领域:
- 免疫学 免疫学 免疫学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 细胞生物学 细胞生物学
背景情况:
- 巨细胞对于天生的免疫力和组织平衡至关重要.
- 它们的身份受到发育和组织微环境的影响.
- 了解染色质修饰是巨细胞专业化的关键.
研究的目的:
- 为了研究本体生殖和微环境如何影响组织居民巨细胞中的染色质状态.
- 确定控制巨细胞身份和可塑性的监管网络.
- 探索组织组织蛋白修饰在定义巨细胞群中的作用.
主要方法:
- 在七个组织居民巨细胞种群中概述了四种基因素修饰.
- 使用染色体可访问性数据识别巨细胞特异性增强剂.
- 整合增强剂数据与基因表达和转录因子概况.
主要成果:
- 发现了12743种巨细胞特异性增强剂,揭示了不同的组织特异性景观.
- 证明增强景观是由发展起源之外的因素塑造的.
- 表明组织和血统转录因子形成了控制染色质特异性的调控网络.
- 证实微环境可以在前体和分化巨细胞中重新编程染色素.
结论:
- 组织居民巨细胞的身份是发育线索和微环境之间的动态相互作用.
- 微环境在编排巨细胞的身份和可塑性方面发挥着至关重要的作用.
- 开拓性转录因子对于建立和维持巨细胞特异性染色质状态至关重要.
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