新的脊椎动物头部的进化是通过古老的状骨组织的合作选择
David Jandzik1, Aaron T Garnett2, Tyler A Square2
11] Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, Colorado 80309, USA [2] Department of Zoology, Comenius University, Bratislava 84215, Slovakia.
Nature
|December 10, 2014
概括
脊椎动物的头骨可能不是从新的组织进化而来,而是从现有的软骨状组织的扩散而来. 基因调节的变化,特别是SoxE,可能促进了神经细胞的进化过渡.
科学领域:
- 进化发育生物学 进化发育生物学
- 比较解剖学的比较解剖学.
- 编号生物学 编号生物学
背景情况:
- 脊椎动物头骨的特点是细胞软骨,通常来自神经细胞.
- 脊椎动物头骨的进化起源与神经脊柱衍生的软骨的出现有关.
- 神经细胞及其衍生的软骨被认为是脊椎动物特有的.
研究的目的:
- 为了研究脊椎动物头骨发育的进化起源.
- 在无脊椎动物中识别脊椎动物软骨和神经细胞的潜在前体.
- 了解基因调节在软骨发育进化中的作用.
主要方法:
- 对布兰基奥斯托马花科 (Florida amphioxus) 幼虫进行软骨状组织的分析.
- 对SoxE基因及其调控元素在状动物进化中的研究.
- 对比的基因组和发育分析.
主要成果:
- 在amphioxus幼虫中发现了一种具有脊椎动物细胞软骨特征的短暂组织.
- 有证据表明,SoxE基因在进化过程中获得了新的cis调节序列.
- 在神经细胞中SoxE的新表达是由这些新的调节序列指导的.
结论:
- 脊椎动物的头骨很可能是通过先前存在的软骨状组织的扩张而进化而来的,而不是新组织的发明.
- 像SoxE这样的古老基因的cis-regulatory元素的进化变化对于指导神经细胞中的组织发育至关重要.
- 这为脊椎动物头骨结构的起源提供了新的视角.
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