兰化物 (Lanthanide) 复合物与强化环结合物显示出前所未有的动力惰性
Aurora Rodríguez-Rodríguez1, David Esteban-Gómez, Raphaël Tripier
1Departamento de Química Fundamental, Universidade da Coruña , Campus da Zapateira-Rúa da Fraga 10, 15008 A Coruña, Spain.
Journal of the American Chemical Society
|December 16, 2014
概括
具有交叉桥接环联体的新型兰坦化物 (III) 复合物表现出异常的动力惰性,在恶劣的酸性条件下甚至超过高度稳定的[Ln(dota) ]-复合物.
科学领域:
- 协调化学 协调化学
- 无机化学 无机化学
- 放射性药物化学 放射性药物化学
背景情况:
- 兰化物复合物在医学成像和治疗中至关重要.
- 高动力惰性对于体内稳定性和有效性至关重要.
- 循环衍生物为稳定的金属复合体提供了有前途的支架.
研究的目的:
- 合成和表征新型兰坦化 (III) 复合物与交叉桥接的环衍生物.
- 在极端条件下评估这些复合物的动力惰性.
- 阐明有助于它们稳定的结构特征.
主要方法:
- 合成兰坦化物 (III) 复合物与具有皮科林酸吊臂的交叉桥式循环联体.
- 在2M HCl.中进行动力惰性研究.
- 对[Eu(cb-tedpa) ](+) 复合物的X射线衍射分析.
- 在D2O中的1H和13CNMR光谱.
- 分析了由Yb(3+) 诱导的偏磁转移.
主要成果:
- 新型兰化物 (III) 复合物表现出显著的动力惰性,在2M HCl中至少5个月没有观察到解离.
- 这些复合物显著优于已知的惰性[Ln(dota) ](-) 复合物,在相同的条件下,这些复合物在几分钟到几个小时内解离.
- X射线衍射揭示了[Eu(cb-tedpa) ](+) 复合体中的联体的八酸结合.
- 核磁共振研究表明,溶液中存在单一的二聚体异构体,这表明它具有从固态保持到固态的刚性结构.
结论:
- 交叉桥接的环状连体赋予了兰化物 (III) 复合体的特殊动力惰性.
- 这些复合物代表了一种新型的高度稳定的合剂.
- 它们的结构刚性和惰性使得它们成为需要高稳定性的应用的有希望的候选者,例如放射性药物.
更多相关视频
10:10Application of Elemental Lanthanides in the Selective C-F Activation of Trifluoromethylated Benzofulvenes Providing Access to Various Difluoroalkenes
Published on: July 28, 2018
7.0K
09:38Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies
Published on: January 3, 2018
7.6K
相关概念视频
01:09Complexation Equilibria: Factors Influencing Stability of Complexes
1.0K
In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
1.0K
01:19Complexation Equilibria: The Chelate Effect
1.7K
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
1.7K
00:43Complexometric Titration: Ligands
2.7K
Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
2.7K
03:02Colors and Magnetism
14.9K
Color in Coordination Complexes
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human...
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human...
14.9K
02:51Metal-Ligand Bonds
25.9K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
25.9K
01:22EDTA: Chemistry and Properties
4.1K
Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...
4.1K