跨鸟类种群的性别染色体的复杂进化轨迹
Qi Zhou1, Jilin Zhang2, Doris Bachtrog3
1Department of Integrative Biology, University of California, Berkeley, CA94720, USA. zhouqi@berkeley.edu zhanggj@genomics.org.cn.
概括
鸟类的性别染色体表现出多种变性,许多W染色体比的染色体更少退化. 这揭示了鸟类性染色体分化和基因丧失的复杂进化历史.
科学领域:
- 基因组学就是基因组学.
- 进化生物学 进化生物学
- 进行比较基因组学.
背景情况:
- 性别特异性染色体 (雌鸟中的W,雄哺乳动物中的Y) 通常由于抑制的重组而失去基因.
- W染色体退化的程度在物种之间有很大差异.
研究的目的:
- 为了研究鸟类性染色体进化的多样性,跨越广泛的基因组范围.
- 了解鸟类Z和W染色体上基因丢失和分化的模式.
主要方法:
- 分析了来自17个不同鸟类物种的新获得的基因组.
- 对Z和W染色体结构的比较基因组分析,包括伪自体区域和基因含量.
- 进化层和重组抑制事件的识别.
主要成果:
- 超过一半的研究鸟类与相比,它们的W染色体变性较小.
- 鸟类的性别染色体组成和Z/W分化中存在显著的跨物种多样性.
- 证据表明,间歇性重组抑制事件在Z染色体上创造了进化层,从DMRT1.1开始.
- 在重组停止后,W-链接基因经历渐进的功能衰变,在较旧的进化层中退化速度较慢.
结论:
- 鸟类的性别染色体进化特点是显著的多样性和复杂的重组抑制和基因退化历史.
- W染色体退化模型在所有鸟类物种中都不统一,这挑战了以为基础的先前假设.
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