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Updated: Apr 19, 2026

A Reporter Based Cellular Assay for Monitoring Splicing Efficiency
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RNA 拼接.RNA 拼接.RNA 拼接.RNA 拼接.RNA 拼接. 人类拼接代码揭示了对疾病遗传决定因素的新见解

Hui Y Xiong1, Babak Alipanahi1, Leo J Lee1

  • 1Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario M5S 3G4, Canada. Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada. Program on Genetic Networks and Program on Neural Computation & Adaptive Perception, Canadian Institute for Advanced Research, Toronto, Ontario M5G 1Z8, Canada.

Science (New York, N.Y.)
|December 20, 2014
PubMed
概括

一个新的机器学习工具预测了基因变异如何影响RNA拼接,这是许多疾病的关键因素. 这种方法可以识别成千上万的致病突变,推进精准医学和全基因组注释.

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