Aδ-LTMRs的方向选择性的细胞和分子基础
Michael Rutlin1, Cheng-Ying Ho2, Victoria E Abraira3
1Solomon H. Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.
Cell
|December 20, 2014
概括
鼠类 Aδ低值机械感知神经元 (LTMRs) 检测头发偏斜方向. BDNF信号引导这些LTMR的两极分化,使得有方向的触摸感知.
科学领域:
- 神经科学是一个神经科学.
- 身体的感官系统 身体的感官系统
- 机械转导是指机械转导的过程.
背景情况:
- 触觉依赖于皮肤中的低值机械感知神经元 (LTMRs).
- LTMRs对于检测刺激至关重要,包括通过皮肤运动的方向.
研究的目的:
- 研究由小鼠Aδ-LTMRs介导的方向选择性触摸感知背后的机制.
- 确定BDNF-TrkB信号在Aδ-LTMR极化及其定向调节中的作用.
主要方法:
- 研究了与毛囊相关的小鼠Aδ-LTMRs的分布和响应特性.
- 研究了BDNF及其受体TrkB在毛囊上皮细胞和Aδ-LTMR中的表达和局部化.
- 在毛囊上皮细胞中利用BDNF的基因切除,以评估其对Aδ-LTMR两极化和功能的影响.
主要成果:
- 鼠Aδ-LTMRs在尾巴到后背头发偏移方面表现出偏好的调整.
- Aδ-LTMR的状末端是两极分化的,集中在毛囊的尾部.
- BDNF是在毛囊尾部,TrkB表达的ADD-LTMR结尾附近合成的.
- 废除BDNF会破坏Aδ-LTMR两极分化,并随机化它们的反应方向.
结论:
- BDNF-TrkB信号传递对于Aδ-LTMR状末端的两极分化至关重要.
- 这种定向偏振是Aδ-LTMRs感知头发偏斜方向的能力的基础.
- 这些发现阐明了定向触摸感觉的分子机制.
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