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Updated: Apr 19, 2026

Kinetic Measurement and Real Time Visualization of Somatic Reprogramming
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Kinetic Measurement and Real Time Visualization of Somatic Reprogramming

Published on: July 30, 2016

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X染色体重新激活的动态揭示了重编程到多能性的阶段

Vincent Pasque1, Jason Tchieu2, Rahul Karnik3

  • 1Department of Biological Chemistry, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.

Cell
|December 20, 2014
PubMed
概括

将体细胞重新编程为诱导多能干细胞 (iPSCs) 涉及逆转X染色体不活化. 这项研究揭示了X染色体再激活 (XCR) 期间的顺序表观遗传变化,DNA脱甲基和Xist沉默对于忠实重编程至关重要.

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