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人类tRNA合成酶是一个强大的PARP1-激活效应因子对象,用于复星

Mathew Sajish1, Paul Schimmel2

  • 1The Skaggs Institute for Chemical Biology, The Scripps Laboratories for tRNA Synthetase Research, Department of Molecular and Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Nature
|December 24, 2014
PubMed
概括

ресвератрол与铁转移RNA合成酶 (TyrRS) 结合,抑制其催化活性并将其重定向到核功能. 这种相互作用刺激了涉及PARP1和NAD的应激反应通路,揭示了白醇的新生理机制.

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