第2组先天性淋巴细胞促进白色脂肪组织的化,并限制肥胖症
Jonathan R Brestoff1, Brian S Kim2, Steven A Saenz2
11] Jill Roberts Institute for Research in IBD, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medical College, Cornell University, New York, New York 10021, USA [2] Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
在人类白色脂肪组织 (WAT) 中的II组先天性淋巴细胞 (ILC2s) 在肥胖中减少. 通过ILC2s发送信号的IL-33 (IL-33) 促进肥胖并增加热量消耗,为肥胖提供了一个新的治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢的恒常状态 代谢的恒常状态
- 脂肪组织生物学 脂肪组织生物学
背景情况:
- 肥胖是一种普遍的代谢疾病,受遗传和环境因素的影响.
- 免疫细胞,包括2组先天性淋巴细胞 (ILC2s),在代谢平衡中发挥作用,但它们在人类脂肪组织中的功能尚不清楚.
- 之前在小鼠白脂肪组织 (WAT) 中发现了ILC2s,这表明它可能在限制肥胖方面发挥作用.
研究的目的:
- 确定人类WAT中的ILC2s并调查它们在肥胖中的作用.
- 阐明ILC2s调节代谢平衡和脂肪的机制.
- 确定Interleukin-33 (IL-33) 在ILC2功能中的作用及其对能源消耗的影响.
主要方法:
- 在人类WAT中识别和描述ILC2s.
- 评估肥胖人与瘦人和小鼠的ILC2反应.
- 在小鼠模型中使用IL-33,ILC2转移和脑内素的体内和体外实验.
- 对解蛋白1 (UCP1) 表达和色脂肪细胞招募的分析.
主要成果:
- 在人类的WAT中确定了ILC2s,在肥胖中观察到反应减少,这在人类和小鼠中是一个保留的发现.
- IL-33对于维持WAT中的ILC2s和通过促进色脂肪细胞招募 (beiging) 和增加热量消耗来限制脂肪性至关重要.
- ILC2s产生甲胺-核胺,直接上调脂肪细胞中的Ucp1表达,驱动自适应性免疫的独立性.
结论:
- 减少WAT中的ILC2反应是人类和小鼠肥胖的标志.
- IL-33/ILC2轴是脂肪组织功能和代谢平衡的关键调节器.
- 由ILC2衍生的脑蛋白代表了一种通过脂肪细胞的作用来调节能量消耗的新机制.
更多相关视频
06:08Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
Published on: May 19, 2023
08:31Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging
Published on: July 1, 2021
相关概念视频
Cells of the Adaptive Immune Response
Lymphoid Cells and Tissues
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Primary Lymphoid Organs
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
B Cell Activation and Differentiation
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
