类似CetZ管蛋白的蛋白质控制了古老细胞的形状
Iain G Duggin1, Christopher H S Aylett2, James C Walsh3
11] Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK [2] The ithree institute, University of Technology Sydney, New South Wales 2007, Australia.
Nature
|December 24, 2014
概括
古代生物拥有与素和FtsZ相关的CetZ蛋白质,这些蛋白质控制细胞形状和运动性,而不是细胞分裂. 这表明细胞骨的作用可能早于真核生物进化,对微生物游泳至关重要.
科学领域:
- 微生物学 微生物学
- 细胞生物学 细胞生物学
- 生物化学 生物化学
背景情况:
- 结核素和FtsZ分别是真核生物和细菌中的关键细胞骨蛋白,具有不同的功能.
- 它们多样化的角色的进化起源仍然不清楚.
- 古代生物与真核生物和细菌都有共同的特征,为早期细胞骨进化提供了洞察力.
研究的目的:
- 调查Archaea中的CetZ蛋白质的结构和功能,这是一个与突和FtsZ相关的独特家族.
- 了解 CetZ 在古细胞生物学中的作用,特别是与细胞分裂和形状有关的作用.
主要方法:
- 进行X射线晶体学以确定CetZ蛋白质结构.
- 在Haloferax volcanii中进行基因失活实验,以评估CetZ功能.
- 在CetZ细胞骨结构的体内成像.
主要成果:
- CetZ蛋白共享FtsZ/蛋白超级家族折叠.
- 在H. volcanii. 中,CetZ的非活化没有影响细胞分裂.
- CetZ1对于将板状细胞分化为棒状细胞至关重要,对于游泳运动性至关重要.
- CetZ1形成了动态的细胞骨结构,参与细胞外重塑和杆形成.
- CetZ2 还有助于控制H. volcanii. 的细胞形状.
结论:
- FtsZ/tubulin超级家族的功能延伸到古细胞形状动态.
- 这些蛋白质的细胞骨作用可能早于真核细胞进化.
- 微生物棒形状可能是促进游泳运动的重要因素.
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