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Updated: Apr 19, 2026

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
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低亲和度结合位点集群赋予霍克斯特异性和监管稳健性.

Justin Crocker1, Namiko Abe2, Lucrezia Rinaldi2

  • 1Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA.

Cell
|January 6, 2015
PubMed
概括

像Ultrabithorax (Ubx) 这样的Hox蛋白通过结合增强剂中的低亲和度DNA位点集群来实现Drosophila中的特定基因调节. 这种增强器架构确保了在可变环境中强大的基因表达.

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