苏格兰的一组1型糖尿病患者的预期寿命,2008-2010年
Shona J Livingstone1, Daniel Levin1, Helen C Looker1
1Diabetes Epidemiology Unit, University of Dundee, Dundee, Scotland.
JAMA
|January 7, 2015
概括
1型糖尿病 (T1D) 患者的预期寿命大约减少了11-13年. 这种显著的寿命缩短与缺血性心脏病和糖尿病酸性脂肪酸症等疾病有关.
科学领域:
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 从历史上看,1型糖尿病 (T1D) 减少了预期寿命.
- 最近的治疗进展需要更新预期寿命估计.
研究的目的:
- 评估苏格兰T1D和没有T1D的个人目前的预期寿命.
- 确定脏疾病是否是T1D患者预期寿命减少的唯一原因.
主要方法:
- 这是一项前性队列研究,对24691名苏格兰T1D成年人 (≥20岁) 进行了前性队列研究 (2008-2010年).
- 分析全国范围的注册数据,包括人年和死亡人数.
- 对T1D和非T1D群体的预期寿命进行比较,检查死亡原因.
主要成果:
- 在20岁时,患有T1D的男性失去11.1年的预期寿命,女性失去12.9年的预期寿命.
- 即使是患有T1D和正常功能的人也经历了预期寿命的缩短 (男性8.3年,女性7.9年).
- 缺血性心脏病占生命损失年数的最大比例 (31-36%),而糖尿病昏迷/酸性糖尿病则对早逝死亡 (<50岁) 贡献最大.
结论:
- 苏格兰的T1D (2008-2010) 与男性在20岁时大约11年的损失和女性在20岁时13年的损失有关.
- 这些发现突显了T1D对寿命的重大影响,即使功能得到保护.
- 心血管疾病和急性并发症仍然是影响T1D生存的关键因素.
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