喘与发展阻塞性睡眠呼吸暂停风险之间的关联
Mihaela Teodorescu1, Jodi H Barnet2, Erika W Hagen2
1James B. Skatrud Pulmonary/Sleep Research Laboratory, William S. Middleton Memorial Veteran's Hospital, Madison, Wisconsin2Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison3Center for Sleep Medicine and Sleep Re.
JAMA
|January 14, 2015
概括
喘与患阻塞性睡眠呼吸暂停 (OSA) 的风险更高有关. 这项研究发现,患有喘的人更有可能发展新发性OSA,特别是喘持续时间较长的人.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 睡眠医学 睡眠医学
- 流行病学 流行病学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 经常在喘患者中观察到,但因果关系尚不清楚.
- 了解喘和OSA发展之间的关系对于患者护理至关重要.
研究的目的:
- 为了前性地研究喘和阻塞性睡眠呼吸暂停 (OSA) 的发生率之间的联系.
主要方法:
- 一项基于人口的前性队列研究 (威斯康星州睡眠队列研究) 在4年间隔跟踪了参与者.
- 喘状况通过问卷进行评估,OSA发病率通过多眠学测定.
- 重复测量Poisson回归被用来分析喘和发生的OSA之间的关联,调整为混因素.
主要成果:
- 患有喘的参与者患上新发性OSA的风险显著增加 (调整后RR,1.39).
- 喘也与伴有习惯性嗜睡的OSA风险较高有关 (调整后RR,2.72).
- 较长的喘持续时间与OSA和OSA与嗜睡的发病率增加相关.
结论:
- 喘是阻塞性睡眠呼吸暂停发展的重要危险因素.
- 建议对潜在机制进行进一步的研究,并建议在喘患者中进行OSA查.
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