天生的淋巴细胞的生物学
1Weill Cornell Medical College, Cornell University, New York, New York 10021, USA.
Nature
|January 17, 2015
概括
天生的免疫系统包括巨细胞和树突细胞等细胞. 最近发现的先天性淋巴细胞对于在感染,炎症,代谢疾病和癌症期间维持组织平衡至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 天生的免疫系统包括多样化的,古老的造血细胞 (例如,巨细胞,树突细胞) 协调免疫,炎症和修复.
- 这些细胞与适应性免疫和非造血细胞相互作用,形成综合生理反应.
研究的目的:
- 总结一下先天性淋巴细胞的正式识别.
- 要突出先天性淋巴细胞在组织平衡中的新兴作用.
主要方法:
- 关于先天性淋巴细胞识别的科学文献的综述.
- 对研究先天性淋巴细胞功能的研究进行分析.
主要成果:
- 正式识别先天性淋巴细胞作为先天性免疫系统的独特组成部分.
- 新出现的证据表明,先天性淋巴细胞参与调节组织平衡.
结论:
- 先天性淋巴细胞代表了最近在了解先天性免疫系统方面取得的重大进展.
- 这些细胞在控制感染,慢性炎症,代谢障碍和癌症方面发挥着至关重要的作用.
相关概念视频
Lymphoid Cells and Tissues
4.0K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
4.0K
Cells of the Adaptive Immune Response
10.3K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
10.3K
Introduction to Lymphatic and Immune System
19.9K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
19.9K
Cells of the Innate Immune Response
10.9K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
10.9K
Primary Lymphoid Organs
17.0K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
17.0K
Functions of the Lymphatic and Immune System
8.4K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
8.4K


