在Cu催化动态动态动力学非对称的基基化中非稳定型核
Hengzhi You1, Emeline Rideau1, Mireia Sidera1
1Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.
Nature
|January 17, 2015
概括
化学家们开发了一种新的铜催化方法,用于动态运动不对称的转换,使单个反体产品的合成从racemic起始材料使用高度基本的核.
科学领域:
- 有机化学 有机化学
- 催化剂是一种催化剂.
- 不对称的合成方法
背景情况:
- 不对称的碳-碳键形成对于合成药品等复杂分子至关重要.
- 目前的方法往往涉及创建新的立体中心或解决种族混合物.
- 动态运动不对称转换提供超过50%的收益率,但与非稳定核友细胞作斗争.
研究的目的:
- 开发一种用于动态动力学非对称转换的新型催化方法.
- 为了使在不对称合成中使用强基性,非稳定型核友的.
- 为了合成聚丰富的天然产品和生物活性化合物.
主要方法:
- 铜催化动态动力学非对称转换的racemic基质.
- 从基因通过水金属化在现场生成有机金属试剂.
- 使用pKa ≥50的基核,明显比以前使用的核更基本.
主要成果:
- 在温和的反应条件下,可以获得高度缩的产品.
- 证明了具有抗结核和抗麻风活性的天然产品的合成.
- 合成了一种对胺基酸生物合成的抑制剂.
- 机械学研究显示,一种快速异构化的中间体.
结论:
- 新的铜催化方法扩大了动态运动不对称转换的范围.
- 这种方法有效地利用了具有挑战性的,高度基本的核友.
- 开发的方法是现有的不对称催化技术的宝贵补充.
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