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瘤的分子和遗传特性与局部免疫细胞分解活性相关

Michael S Rooney1, Sachet A Shukla2, Catherine J Wu3

  • 1The Broad Institute, Cambridge, MA 02142, USA; Harvard/MIT Division of Health Sciences and Technology, Cambridge, MA 02141, USA.

Cell
|January 17, 2015
PubMed
概括

瘤基因组学通过免疫编辑影响抗瘤免疫力. 在β-2-微球蛋白 (B2M) 和HLA基因中的关键突变,以及PD-L1/2的放大,揭示了瘤抵抗免疫攻击的机制.

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