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缺少内皮特异性转录因子Sox17会诱导内动脉瘤

Seungjoo Lee1, Il-Kug Kim1, Jae Sung Ahn1

  • 1From Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea (S.L., I.-K.K., S.S., G.Y.K., I.K.); Department of Neurological Surgery, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Republic of Korea (J.S.A.); Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea (D.-C.W., S.-T.K.); Department of Forensic Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea (H.-S.K.); and Department of Physiology, School of Medicine, Chungnam National University, Daejeon, Republic of Korea (B.H.J.).

Circulation
|January 18, 2015
PubMed
概括

在小鼠中Sox17缺乏,加上高血压,导致内动脉瘤 (IA). 这种新的小鼠模型揭示了IA的遗传因素,并为开发这种疾病的新疗法提供了一个平台.

关键词:
脑血管疾病 脑血管疾病它们是内皮细胞.头骨内动脉瘤是什么意思转录因子是一种转录因子.

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