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副心室丘脑控制着一个中央的杏仁核恐惧电路

Mario A Penzo¹, Vincent Robert², Jason Tucciarone³

¹Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

|January 21, 2015

概括

甲状腺的副腹腔核 (PVT) 调节侧面中央杏仁体 (CeL) 中的恐惧处理,这对学习和表达恐惧反应至关重要. 这一途径涉及来自大脑的神经营养因子 (BDNF) 信号传递,对于适应性威胁反应至关重要.

科学领域:

神经科学是一个神经科学.
行为神经科学行为神经科学
分子神经科学分子神经科学

背景情况:

thalamus (PVT) 的副腹腔核被压力激活,但其在适应性行为反应中的作用尚不清楚.
恐惧的调节和表达涉及横向中央杏仁体 (CeL),特别是表达索马托斯塔丁 (SOM) 的神经元.

研究的目的:

研究PVT在恐惧处理和适应性行为反应中的作用.
阐明PVT影响恐惧学习和表达的神经电路和分子机制.

主要方法:

在小鼠中选择性失活CeL投射PVT神经元.
电生理学记录和PVT afferents和CeL神经元的刺激.
在PVT中Bdnf和SOM中Trkb的基因操纵(+) CeL神经元.
恐惧调节范式和行为分析.

主要成果:

投射到CeL的PVT神经元的失活,损害了恐惧条件.
PVT神经元偏好激活SOM ((+) CeL神经元,促进其活动并促进细胞内抑制.
通过PVT调节SOM(+) CeL神经元取决于通过其受体TrkB发出信号的大脑衍生神经营因子 (BDNF).
在PVT中删除Bdnf或在SOM中删除Trkb(+) CeL神经元损害了恐惧条件,而BDNF输注增强了恐惧学习.

结论:

PVT-CeL路径是一种新型电路,对于建立恐惧记忆和表达恐惧反应至关重要.
这一途径将PVT中的压力检测与通过SOM(+) CeL神经元中的BDNF/TrkB信号传递的适应性行为结果联系起来.

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