皮和前额皮层与证据积累的明显关系
Timothy D Hanks1, Charles D Kopec1, Bingni W Brunton2
11] Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey 08544, USA [2] Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
Nature
|January 21, 2015
概括
神经调曲线揭示了在决策过程中大脑区域编码的明显证据. 后壁皮层显示分级的证据积累,而前部定位场 (FOF) 使用分类信号来决定决心.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 决策研究 决策研究
背景情况:
- 决策依赖于积累的感官证据.
- 证据积累的神经相关物体在各种大脑区域中被发现.
- 了解不同大脑区域如何编码决策变量至关重要.
研究的目的:
- 开发一种可通用的方法来测量与累积的证据相关的神经调曲线.
- 为了区分决策变量的编码在后壁皮质和正面定向场 (FOF) 中.
- 研究FOF活动在决策过程中的因果关系作用.
主要方法:
- 在感知决策任务期间,在老鼠后壁皮质和FOF中记录了神经元发射率.
- 应用了新的调曲线测试来分析神经反应.
- 在不同的试验阶段使用了FOF的光遗传沉默来探测因果作用.
主要成果:
- 后壁皮层神经元以分级的方式编码积累证据.
- 前额定位场 (FOF) 神经元表现出分类编码,反映了临时决定.
- 在刺激呈现结束时,FOF的光遗传沉默,但在受影响的行为期间没有.
结论:
- FOF在决策中扮演着明确的角色,可能是选择承诺,而不是证据积累.
- 这挑战了关于前运动皮层在决策中的作用的现有观点.
- 这些发现为大脑决策的电路逻辑提供了洞察力.
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