肺炎住院和随后心血管疾病风险之间的关联
Vicente F Corrales-Medina1, Karina N Alvarez2, Lisa A Weissfeld3
1Department of Medicine, University of Ottawa, Ottawa Ontario, Canada2Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
肺炎住院显著增加了短期和长期心血管疾病 (CVD) 的风险. 这表明肺炎可能是发展心血管疾病的独立风险因素.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 感染后的心血管疾病 (CVD) 风险仍然不太了解.
- 肺炎是一种常见的感染,但其对心血管健康的长期影响尚未得到充分证实.
研究的目的:
- 研究因肺炎住院和随后患心血管疾病的风险之间的关联.
- 要确定这种关联在肺炎住院后的短期和长期期间之间是否有所不同.
主要方法:
- 分析了两个大型社区群体 (心血管健康研究和社区动脉样硬化风险研究) 的长期随访.
- 将肺炎病例与对照病例相匹配,并分析10年内发生的心血管疾病事件 (心肌梗塞,中风,致命的冠心病).
- 调整人口统计,心血管疾病风险因素,并发症和功能状态以估计危险比率 (HR).
主要成果:
- 肺炎住院与心血管疾病的短期风险显著增加有关,特别是在第一年.
- 在心血管健康研究队列中,心血管疾病风险升高持续到住院后的第十年.
- 社区动脉样硬化风险研究也显示,在前两年心血管疾病风险增加,在第二年后,危险比率不再具有统计学意义.
结论:
- 肺炎住院与心血管疾病的短期和长期风险增加有关.
- 这些发现表明,肺炎可能是心血管疾病发展的独立风险因素.
- 需要进一步的研究来阐明肺炎和心血管事件之间的联系机制.
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