与癌症相关的蛋白激酶C突变揭示了激酶作为瘤抑制剂的作用

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Corina E Antal1, Andrew M Hudson2, Emily Kang3

  • 1Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA; Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, CA 92093, USA.

Cell
|January 27, 2015
PubMed
概括

蛋白激酶C (PKC) 异酶通常是瘤抑制剂,而不是激活剂. 大多数癌症突变导致功能丧失,这表明治疗应该恢复,而不是抑制PKC活性用于癌症治疗.

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