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由拓聚酶-I活性调节的依赖体增强剂激活

Janusz Puc1, Piotr Kozbial1, Wenbo Li1

  • 1Howard Hughes Medical Institute, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0648, USA.

Cell
|January 27, 2015
PubMed
概括

研究人员发现,DNA拓酶I (TOP1) 的DNA切割对于激活增强剂和合成增强剂RNA (eRNA) 是必不可少的. 这个由二测试 (DHT) 和雄激素受体 (AR) 触发的过程涉及DNA修复机械的招募.

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