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改善帕克利塔塞尔的输送:以PEGylated聚聚乙烯为基础的纳米载体的体外和体外表征

Fuwu Zhang¹, Shiyi Zhang, Stephanie F Pollack

¹Departments of Chemistry, Chemical Engineering, and Materials Science and Engineering, ‡Laboratory for Synthetic-Biologic Interactions, and §Texas A&M Institute for Preclinical Studies, Texas A&M University , College Station, Texas 77842, United States.

Journal of the American Chemical Society

|January 29, 2015

概括

新型可生物降解的纳米颗粒有效地提供高度的帕克利塔塞尔 (PTX) 持续释放,显示出治疗骨髓瘤肺转移的前景.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
药理学药理学是指药理学的学科.

背景情况:

纳米材料为治疗疾病提供局部,持续的药物输送.
开发出了可生物降解的基于聚聚的纳米粒子 (和交联的状纳米粒子 - - SCKs).

研究的目的:

设计和描述新型纳米结构,用于高度,持续的帕克利塔克塞尔 (PTX) 输送.
调查这些纳米疗法在骨肉瘤肺转移治疗中的结构功能关系.

主要方法:

两性块接种聚合物 (PEBP-b-PBYP-g-PEG) 用于制造带PTX的和SCKs.
评估了物理化学特征,药物负载,释放动力学和体外/体内疗效.

主要成果:

与单独使用药物 (<2.0微克/毫升) 相比,纳米颗粒实现了高PTX悬浮 (4.8毫克/毫升).
在SCKs的交叉链接使PTX的持续释放半衰期翻了一番.
在体外研究表明,Taxol对骨髓瘤细胞系的疗效与Taxol相似;在体内研究评估了内内传递和药理动力学.

结论:

新型PTX载和SCK显示了持续药物释放的潜力.
纳米粒子结构显著影响药物释放动力学和治疗结果.
这些纳米疗法在局部治疗骨肉瘤肺转移方面表现有前途.

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