性综合征:从幼儿到二十多岁
M A Lewis1, E M Baildom, N Davis
1Royal Manchester Children's Hospital, Pendlebury.
Lancet (London, England)
|February 4, 1989
概括
微小变化性综合征患者经常实现缓解,但复发可能持续到成年. 长期随访显示,大多数幸存者的功能持续正常.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 儿科脏病学 儿科脏病学
- 内部医学 内部医学
背景情况:
- 最小变化综合征 (MCNS) 是儿童综合征的常见原因之一.
- 虽然经常对类固醇有反应,但长期结果和复发模式需要进一步阐明.
研究的目的:
- 为了评估长期预后和复发频率在活检证明,类固醇敏感的最小变化瘤综合征的患者.
- 确定影响复发模式的因素,并确定是否存在明确的终点.
主要方法:
- 一项回顾性队列研究跟踪了63名活检证明的,对类固醇敏感的MCNS患者10-21年.
- 收集的数据包括发病时的年龄,性别,复发频率,功能和血压.
主要成果:
- 在63名患者中,有2人死亡;幸存者表现出正常的功能和血压.
- 只有2名幸存者经历过一次复发;频繁的复发与较年轻的发病年龄和男性性别有关.
- 复发频率在诊断后4年内显著下降,然后稳定,在成年后继续复发.
结论:
- 对类固醇敏感的MCNS通常具有有利的长期预后,功能保持良好.
- 复发模式随着时间的推移而演变,在最初几年后出现平原,并且可以延伸到成年.
- 没有明确的终点被确定,缓解的持续时间与随后的复发风险相关.
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