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在20种哺乳动物物种中增强进化
Diego Villar1, Camille Berthelot2, Sarah Aldridge1
1University of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, CB2 0RE, UK.
Cell
|January 31, 2015
概括
哺乳动物的调节进化显示了快速增强剂的变化,通常来自祖先的DNA抽取,而肝脏促进剂仍然保留. 这揭示了对哺乳动物基因组功能遗传学的关键见解.
科学领域:
- 基因组学就是基因组学.
- 进化生物学 进化生物学
- 分子生物学分子生物学
背景情况:
- 哺乳动物辐射与快速的基因组变化相吻合,特别是在非编码区域.
- 缺乏对哺乳动物调节进化的全面理解.
研究的目的:
- 研究哺乳动物肝脏中促进剂和增强剂的进化动态.
- 确定驱动不同哺乳动物物种监管进化的机制.
主要方法:
- 分析H3K27乙化和H3K4三甲基化基因组丰富.
- 在20种哺乳动物中进行了对比分析,来自六个不同的类.
主要成果:
- 增强剂的快速进化是哺乳动物基因组的普遍特征.
- 大多数新的增强剂来源于祖先的DNA扩张,而不是重复元素扩张.
- 在研究的哺乳动物物种中,肝脏促进剂在很大程度上得到保护.
- 最近演变的增强剂可以在积极选择下与基因联系起来.
结论:
- 增强器进化,主要是通过DNA抽取,是哺乳动物调节适应的主要驱动因素.
- 促进者保护表明肝脏基本功能的稳定监管框架.
- 这项研究为注释监管适应和理解哺乳动物进化中的功能遗传学提供了一个框架.
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