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Updated: Apr 17, 2026

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迪亚佐基团耐受新陈代谢,并使纤维素的化学选择性成为可能

Kristen A Andersen1, Matthew R Aronoff, Nicholas A McGrath

  • 1Molecular & Cellular Pharmacology Graduate Training Program, ‡Department of Chemistry, and §Department of Biochemistry, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.

Journal of the American Chemical Society
|February 7, 2015
PubMed
概括

研究人员开发了ManDiaz,一种新的基于diazo的分子,用于细胞标签. 这种记者分子在细胞中稳定,并使独特的双重标记策略成为可能,而传统的亚齐多群是不可能的.

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The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the...
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All meta-directing substituents are deactivating groups. These substituents withdraw electrons from the aromatic ring, making the ring less reactive toward electrophilic substitution. For example, the nitration of nitrobenzene is 100,000 times slower than that of benzene because of the deactivating effect of the nitro group. The first step in an electrophilic aromatic substitution is the addition of an electrophile to form a resonance-stabilized carbocation. The energy diagrams for...
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