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Updated: Apr 17, 2026

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay
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在亲和力成熟过程中操纵选择力以产生交叉反应性HIV抗体

Shenshen Wang1, Jordi Mata-Fink2, Barry Kriegsman3

  • 1Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139.

Cell
|February 10, 2015
PubMed
概括

生成交叉反应性抗体对于对抗可变病原体至关重要. 与尾酒不同的是,用抗原变体进行序列免疫是诱导这些抗体的首选方法,正如in silico模型和小鼠实验所显示的那样.

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