献血后口服补充铁:一个随机临床试验
Joseph E Kiss1, Donald Brambilla2, Simone A Glynn3
1Institute for Transfusion Medicine, Pittsburgh, Pennsylvania.
JAMA
|February 11, 2015
概括
口服铁补充剂显著加快血红蛋白和铁储存恢复在献血者. 这种干预措施有助于捐赠者,特别是那些铁素含量低的捐赠者,在捐赠后更快地补充铁含量.
科学领域:
- 血液学 血液学 血液学
- 营养科学 营养科学
- 输血医学 输血医学
背景情况:
- 在美国,每8周允许献血一次.
- 血液中血红蛋白恢复到12.5g/dL通常会在捐献后延迟.
- 一些献血者因延迟恢复而患有贫血.
研究的目的:
- 评估口服铁对血红蛋白恢复时间的影响.
- 为了评估血液捐献者的铁储存补充.
- 为了比较缺铁 (低费里) 与补铁 (高费里) 捐赠者的效果.
主要方法:
- 在4个美国血液中心进行随机,非盲目的临床试验.
- 215名参与者 (年龄在18-79岁之间) 按费里丁,性别和年龄分层.
- 干预措施:在捐赠后24周内,每天服用铁酸盐 (37.5毫克元素铁) 或安慰剂.
主要成果:
- 补充铁减少了80%的血红蛋白恢复时间,无论是在低酸蛋白 (32对158天) 和高酸蛋白 (31对78天) 组.
- 平均恢复到基线费里是21天 (低费里) 和107天 (高费里) 铁.
- 没有铁,67%的参与者在168天内没有恢复铁储量.
结论:
- 低剂量的铁补充剂加速了捐赠后的血红蛋白恢复.
- 铁补充剂有效地恢复了献血者体内的铁储量.
- 这一策略既有利于缺铁的捐赠者,也有利于补铁的捐赠者.
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