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Updated: Apr 17, 2026

Purification of Hsp104, a Protein Disaggregase
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Published on: September 30, 2011

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进化保守的Tyr169稳定了质蛋白的β2-α2循环

Danzhi Huang1, Amedeo Caflisch

  • 1Department of Biochemistry University of Zürich , Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.

Journal of the American Chemical Society
|February 12, 2015
PubMed
概括

蛋白的β2-α2循环结构是其转换的关键. 一个特定的突变 (Y169G) 降低了这种循环过渡的能量屏障,影响了聚.

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