针对婴儿急性中耳炎,随机对线索切除术,阿莫西西林/克拉夫兰酸或两者的研究
D Engelhard1, D Cohen, N Strauss
1Department of Clinical Microbiology, Hadassah University Hospital, Jerusalem, Israel.
Lancet (London, England)
|July 15, 1989
概括
阿莫西西林/克拉夫兰酸 (Augmentin) 有效地治疗婴儿中耳炎. 对于婴儿耳部感染,Augmentin,带或不带耳环切除术,显示的康复率高于单独的耳环切除术.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 急性中耳炎 (AOM) 是一种常见的儿童感染.
- 像Haemophilus influenzae和Streptococcus pneumoniae这样的细菌病原体是AOM的主要原因.
- 治疗选项包括抗生素和手术干预,如线索切除术.
研究的目的:
- 为了比较阿莫西西林/克拉夫兰酸盐 (Augmentin) 与线索切除术在婴儿AOM治疗中的疗效.
- 为了评估当与Augmentin疗法相结合时,myringotomy的额外好处.
主要方法:
- 一项前性随机研究,涉及105名患有AOM的婴儿 (3-12个月).
- 三个治疗组:单独使用augmentin,使用安慰剂进行myringotomy,使用augmentin进行myringotomy.
- 对耳部排泄物的细菌培养进行了分析,以确定病原体和抗生素敏感性.
主要成果:
- 与安慰剂 myringotomy 相比,阿莫西西林/克拉夫兰酸在实现完全康复方面表现出更高的疗效 (60%vs23%).
- 在解决持久性耳部感染方面,augmentin治疗更有效.
- 虽然耳环切除术加速了切口愈合,但其添加到阿格曼丁并没有显著影响感染持久性或中耳溢出.
结论:
- 阿莫西西林/克拉夫兰酸是婴儿急性中耳炎的有效治疗方法.
- 单独进行线索切除术对AOM的抗生素治疗效果不如.
- 将线索切除术与阿莫西西林/克拉夫兰酸相结合,为AOM解决提供了与单独抗生素治疗相比有限的额外益处.
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