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通过癌症特异性泛素结合酶降解AMPK

Carlos T Pineda1, Saumya Ramanathan1, Klementina Fon Tacer1

  • 1Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Cell
|February 14, 2015
PubMed
概括

癌细胞通过劫持涉及MAGE-A3/6-TRIM28.28的生殖系机制来抑制AMP激活蛋白激酶 (AMPK). 这导致AMPKα1降解,促进癌症生长和对向AMPK的药物的敏感性.

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