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使用双功能小分子转向基因工程CAR-T细胞.

Min Soo Kim1, Jennifer S Y Ma, Hwayoung Yun

  • 1California Institute for Biomedical Research , 11119 North Torrey Pines Road, Suite 100, La Jolla, California 92037, United States.

Journal of the American Chemical Society
|February 19, 2015
PubMed
概括

一种新的叶酸-FITC分子开关能够精确控制仿真抗原受体 (CAR) -T细胞疗法. 该系统通过向叶酸受体过度表达的瘤来提高安全性,并允许对CAR-T细胞活性进行剂量依赖的调节.

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