固性白痴症:甲状腺自身免疫的可能作用
S C Boyages1, J P Halpern, G F Maberly
1Department of Medicine, Westmead Hospital, Sydney, Australia.
Lancet (London, England)
|September 2, 1989
概括
形腺缩在形腺的特有形症与阻断甲状腺生长的特定IgG抗体有关. 这一发现解释了这种疾病的各种临床表现.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 甲状腺缩是myxoedematouscretinism的一个关键特征,但其原因仍然不清楚.
- 地方性形症具有可变的临床表现,包括神经和甲状腺异常.
研究的目的:
- 为了研究免疫球蛋白G (IgG) 在状腺缩的发病过程中的作用.
- 为了确定潜在的致病因素,有助于各种临床结果在流行性形.
主要方法:
- 用细胞化学生物试验,测试了来自肌肉发疹性特异性形症患者的净化IgG分离物对几内亚猪甲状腺片段中甲状腺激发的DNA合成的影响.
- 血清IgG从euthyroid特有形症患者和正常受试者作为对照.
- 超声波被用来评估甲状腺缩在myxoedematous受试者.
主要成果:
- 来自肌肉发育性特异性形症患者的IgG显著抑制了几内亚猪甲状腺细分中的甲状腺激素诱导的DNA合成.
- 来自于甲状腺特异性形症患者和正常人群的IgG对甲状腺生长没有表现出抑制作用.
- 在甲状腺增长阻断免疫球蛋白的存在和甲状腺缩之间观察到一种积极的相关性.
结论:
- 甲状腺增长阻断性免疫球蛋白在疹性特异性形症患者的IgG部分中,在甲状腺缩中起病原性作用.
- 这些发现为特有形主义的可变临床表达提供了分子基础,将特定的自身抗体与甲状腺病理联系起来.
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