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非正规的二次结构通过降低三级折叠的热性成本来稳定线粒体tRNA (((Ser (((UCN))

Anthony M Mustoe, Xin Liu, Paul J Lin

  • 1∥Departments of Biochemistry and Chemistry, Duke University School of Medicine, Durham, North Carolina 27710, United States.

Journal of the American Chemical Society
|February 24, 2015
PubMed
概括

线粒体tRNA (mt-tRNA) 的拓约束抵消了失去的三级相互作用,稳定了它的结构. 破坏这些约束的致病突变使mt-tRNA不稳定,将其与聋和等疾病联系起来.

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