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一个单一的谷氨酸残留在兰巴抑制剂的转录激活功能中起着关键作用

F D Bushman1, C Shang, M Ptashne

  • 1Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892.

Cell
|September 22, 1989
PubMed
概括

兰巴抑制剂的激活区域中的负电荷对于转录激活至关重要. 特定的酸性残留物,特别是谷氨酸,是关键的,而基本的残留物阻碍了功能.

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