在危急病患者中,用普罗波福和米达佐拉姆进行镇静的比较
A R Aitkenhead1, M L Pepperman, S M Willatts
1Department of Anaesthesia, Leicester Royal Infirmary.
Lancet (London, England)
|September 23, 1989
概括
普罗波福和米达佐拉姆有效地镇静了重症患者. 与米达佐拉姆相比,普罗波在机械通风中提供了更快的恢复和更快的断奶.
科学领域:
- 麻醉学 麻醉学
- 关键护理医学 关键护理医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 镇静对于重症病患在重症监护室的管理至关重要.
- 普罗波福和米达佐拉姆是常用的静脉静止剂.
- 将这些药物的疗效和安全性进行比较对于优化患者护理很重要.
研究的目的:
- 为了比较propofol与midazolam在重症患者的持续静脉静止治疗中的疗效和安全性.
- 评估在停止使用普罗波福和米达佐拉姆后恢复意识和机械通风断奶时间.
主要方法:
- 一项随机对照试验,涉及五个重症监护病房的101名危急病患者.
- 患者接受了多达24小时的propofol或midazolam连续静脉注射,以及用于止痛的吗啡.
- 输液速率调整以达到所需的镇静水平,并监测血液动力学,生物化学和血液学变量.
主要成果:
- 普罗波和米达佐拉姆都在血动力学差异最小的情况下实现了充分的镇静作用,尽管在普罗波时心率较低.
- 没有观察到对生物化学,血液学变量或上腺类固醇生成的显著不良影响.
- 接受普罗波的患者在恢复意识方面变化较小,并且在机械通风后断奶速度明显更快.
结论:
- 普罗波是一种令人满意和有效的药物,用于镇静重症患者.
- 普罗波与米达佐拉姆相比具有优势,包括更可预测的恢复和更快的从机械通风中释放.
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