使用奇拉酸,对的昂贵芳化剂进行反丰富
Andrew W Lankenau1, Diana A Iovan2, Jared A Pienkos1
1†Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.
Journal of the American Chemical Society
|February 25, 2015
概括
这项研究提出了一种新的方法,用于溶解 dearomatization试剂TpW ((NO) ((PMe3) ((η ((2) -). 该工艺利用二二盐与二酸的二二盐的形成,以进行烯复合物的性分离.
科学领域:
- 有机金属化学 有机金属化学
- 基质合成 基质合成 基质合成
- 催化剂是一种催化剂.
背景情况:
- Dearomatization反应在有机合成中至关重要.
- 对有机金属复合物的化分离对于不对称的催化是必不可少的.
- 复合物TpW ((NO) ((PMe3) ((η(2) -) 是一种多用途的脱氧化试剂.
研究的目的:
- 开发一种用于TpW(NO)(PMe3)(η(2) -的奇拉分辨率的方法.
- 为了使人们能够获得这种重要的试剂的化纯形式.
- 建立一个可靠的路线来确定立体中心的绝对配置.
主要方法:
- 合成复合物的1,3-二甲基 (DMB) 模拟物.
- 将协调的DMB连接体与二醇葡萄酸 (DBTH2) 进行质子化,以形成二聚体盐.
- 选择性沉和单个二聚体盐的分离.
- 脱和连接物交换产生基丰富的TpW () () () () () .
- 使用 (S) -β-平烯和二维NMR光谱学确定绝对配置.
主要成果:
- 成功合成了复合物的DMB模拟物.
- 选择性沉一个单一的二聚体盐,使得奇拉分辨率.
- 制造TpW (TpW) 的R或S形式的二烯 (TpW) 二二二二).
- 展示了一种方法来确定立体中心的绝对配置.
结论:
- 已经建立了一种实用和有效的方法,用于TpW (TpW) (NO) (PMe3) (η) (2) -的奇拉分辨率.
- 这种分辨率方法提供了对化剂的接触.
- 开发的技术允许确定中心的绝对立体化学.
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