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Transnuclear Mice with Pre-defined T Cell Receptor Specificities Against Toxoplasma gondii Obtained Via SCNT
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在表达II类MHC受限抗原受体的转基因小鼠中,CD4+ T细胞的选择性发育

J Kaye1, M L Hsu, M E Sauron

  • 1Department of Biology, University of California, San Diego, La Jolla 92093.

Nature
|October 26, 1989
PubMed
概括

胸腺中的T细胞发育涉及积极选择,其中识别自我MHC分子的T细胞存活下来. 这项研究表明,T细胞受体 (TCR) 对MHC分子的特异性在胸膜选择过程中决定了T细胞表型.

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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...