恒温,炎症和易受疾病的影响
Maya E Kotas1, Ruslan Medzhitov2
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT USA.
Cell
|February 28, 2015
概括
现代化增加了寿命,但也增加了诸如肥胖和糖尿病等慢性疾病,而这些疾病是恒温的失败. 本综述探讨了可调节设定点的适应性恒温系统如何变得易受调节失调和炎症的影响.
科学领域:
- 生理学 生理学 生理学
- 系统生物学 系统生物学
- 病理生理学 病理生理学
背景情况:
- 现代化增加了人类的寿命,但也增加了慢性疾病的患病率,如肥胖,高血压和2型糖尿病.
- 这些慢性疾病被视为平衡的失败,正常的生理控制机制被破坏.
- 慢性炎症经常与这些疾病有关,但根本的联系仍然不清楚.
研究的目的:
- 检查在细胞,组织和有机体层面的恒温系统及其控制电路的设计.
- 提出一个框架来根据它们报告的变量对恒温信号进行分类.
- 讨论恒温系统的适应性如何促进疾病易受伤害和炎症.
主要方法:
- 审查关于恒温系统和控制电路的现有文献.
- 开发一个概念框架来分类恒温信号.
- 分析同居静态系统适应能力与疾病发病之间的关系.
主要成果:
- 恒温系统共享在多个生物层面上运行的通用控制电路特征.
- 一个新的框架根据报告的变量对恒温信号进行分类.
- 恒温系统的适应性,特别是可调节的设置点,会导致对调节失调和疾病的脆弱性.
结论:
- 了解恒温系统的设计和适应性,可以了解疾病的起源.
- 拟议的框架突出显示了恒常和炎症控制之间的平行.
- 这种观点为慢性疾病中炎症的生理基础提供了新的理解.
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